Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma
نویسندگان
چکیده
منابع مشابه
Cholangiocarcinoma Associated with Liver Fluke Infection in an Iranian Patient
Biliary liver flukes are common parasites in some regions of the world where consumption of raw fresh-water fish is a cultural practice. Clonorchis sinensis and Opisthorchis species are the major biliary liver flukes associated with human disease. Some of these parasites are highly associated with cholan...
متن کاملLiver Fluke Induces Cholangiocarcinoma
Liver fl uke infection caused by Opisthorchis viverrini, O. felineus, and Clonorchis sinensis is a major public health problem in East Asia and Eastern Europe. Currently, more than 600 million people are at risk of infection with these trematodes [1]. O. viverrini is endemic in Southeast Asian countries, including Thailand, Lao People’s Democratic Republic, Vietnam, and Cambodia [2], and C. sin...
متن کاملContribution of RIZ1 to regulation of proliferation and migration of a liver fluke-related cholangiocarcinoma cell.
PURPOSE Retinoblastoma-interacting zinc finger gene (RIZ1) is a tumor suppressor gene which is highly inactivated by promoter hypermethylation in patients with liver fluke-related cholangiocarcinoma (CCA). Epigenetic aberration of this gene might withdraw the ability to restrain tumor cell proliferation and migration. We aimed to define the role of RIZ1 on cell proliferation and migration in CC...
متن کاملcholangiocarcinoma associated with liver fluke infection in an iranian patient
biliary liver flukes are common parasites in some regions of the world where consumption of raw fresh-water fish is a cultural practice. clonorchis sinensis and opisthorchis species are the major biliary liver flukes associated with human disease. some of these parasites are highly associated with cholangiocarcinoma. this report describes a clinically and epidemiologically unsuspected liver flu...
متن کاملLeptin enhances cholangiocarcinoma cell growth.
Cholangiocarcinoma is a strongly aggressive malignancy with a very poor prognosis. Effective therapeutic strategies are lacking because molecular mechanisms regulating cholangiocarcinoma cell growth are unknown. Furthermore, experimental in vivo animal models useful to study the pathophysiologic mechanisms of malignant cholangiocytes are lacking. Leptin, the hormone regulating caloric homeostas...
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ژورنال
عنوان ژورنال: Molecular Cancer
سال: 2011
ISSN: 1476-4598
DOI: 10.1186/1476-4598-10-102